A doctor and his wife go to Paris for a medical conference. While showering, his wife disappears. His lack of language, and the odd way she disappeared makes it nearly impossible for him to find any official help in his search as he enters the punk/drug culture to find out what has happened to her.

Tomas is a doctor and a lady-killer in 1960s Czechoslovakia, an apolitical man who is struck with love for the bookish country girl Tereza; his more sophisticated sometime lover Sabina eventually accepts their relationship and the two women form an electric friendship. The three are caught up in the events of the Prague Spring (1968), until the Soviet tanks crush the non-violent rebels; their illusions are shattered and their lives change forever.